Penulis : 
Siti Mudrikatin
Reny I'tishom 
Rochmah Kurnijasanti
Budi Prasetyo
Sri Agus Sudjarwo
Jusak Nugraha

Judul Buku : Molecular Mechanisms Of Ethanolic Extract Of Zingiber Officinale Var. Rubrum As A Protector Against Polycystic Ovary Syndrome In Rattus Norvegicus

Kode Buku : P507

Ukuran: 15,5 cm x 23 cm
Jml Hal: 124 hlm
No. ISBN: 
Terbit: -
Harga: -
Penerbit: Penerbit Buku Sonpedia

Sinopsis :
Polycystic Ovary Syndrome (PCOS) affects millions of women worldwide and remains a complex reproductive–metabolic disorder characterized by insulin resistance, hormonal imbalance, oxidative stress, and chronic low-grade inflammation. This groundbreaking scientific volume explores the molecular mechanisms that underlie PCOS and investigates the protective potential of Zingiber officinale var. rubrum—Indonesia’s distinctive red ginger variety—as a promising herbal intervention.
Drawing from contemporary biomedical research and traditional ethnopharmacology, the book integrates in vivo rat models, in silico molecular docking studies, and phytochemical analyses to reveal how red ginger bioactives such as 8-gingerol and 10-shogaol exert antioxidant, anti-inflammatory, and insulin-sensitizing effects. These compounds are shown to downregulate NF-κB and TNF-α expression, reduce MDA formation, enhance antioxidant enzyme activity (SOD, CAT, GPx), and restore ovarian function through improved IRS-1 and PI3K/Akt signaling.
Blending experimental evidence with translational insights, this monograph bridges Indonesia’s herbal wisdom with modern molecular science. It positions red ginger not only as a traditional remedy but also as a candidate for future phytopharmaceutical and functional-food development in women’s reproductive health. Richly referenced and methodologically rigorous, this book serves as an essential resource for biomedical researchers, pharmacologists, herbal medicine scholars, and clinicians pursuing integrative strategies for managing PCOS.